A. Valance Washington, PhD

A. Valance Washington, PhD

A. Valance Washington, PhD
Associate Professor, Department of Biology
787-764-000 ext. 2898
University of Puerto Rico – Rio Piedras Campus

Role of Platelet Receptor and TREM-Like Transcript -1 in the Regulation of the Immune Response in Coagulation and Disease

1. Soluble Trem-Like Transcript-1 regulates leukocyte activation and controls microbial sepsis.  Derive M, Bouzza Y, Sennoun N, Marchionni S, Quigley L, Washington V, Massin F, Max JP, Ford J, Alauzet C, Levy B, McVicar DW, Gibot S.  J Immunol. 2012 Jun 1;188(11):5585-92.
2. Soluble TLT-1 modulates platelet-endothelial cell interactions and actin polymerization. Morales J, Villa K, Gattis J, Castro W, Colon K, Lubkowski J, Sanabria P, Hunter R, Washington AV. Blood Coagul Fibrinolysis. 2010 Apr;21(3):229-36. PMID: 20093931
3. TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans. Washington AV, Gibot S, Acevedo I, Gattis J, Quigley L, Feltz R, De La Mota A, Schubert RL, Gomez-Rodriguez J, Cheng J, Dutra A, Pak E, Chertov O, Rivera L, Morales J, Lubkowski J, Hunter R, Schwartzberg PL, McVicar DW. J Clin Invest. 2009 Jun;119(6):1489-501. PMID: 19436112
4. Phenotypic heterogeneity in the Gray platelet syndrome extends to the expression of TREM family member, TLT-1. Nurden AT, Nurden P, Bermejo E, Combrié R, McVicar DW, Washington AV. Thromb Haemost. 2008 Jul;100(1):45-51. PMID: 18612537
5. Combined resveratrol, quercetin, and catechin treatment reduces breast tumor growth in a nude mouse model. Schlachterman A, Valle F, Wall KM, Azios NG, Castillo L, Morell L, Washington AV, Cubano LA, Dharmawardhane SF. Transl Oncol. 2008 Mar;1(1):19-27. PMID: 18607509