Raymond DuBois, MD, PhD

Raymond DuBois, MD, PhD

Raymond DuBois, MD, PhD
Executive Center Director and Professor
The Biodesign Institute at Arizona State University

Raymond DuBois, MD, PhD, is the executive director of the Biodesign Institute at Arizona State University. Biodesign is a research institute engaged in addressing critical global challenges in health care, sustainability and security by developing solutions inspired from natural systems that are then translated into commercially viable products and practices. DuBois has joint ASU appointments as the Dalton Chair, School of Health Solutions; and Professor, Department of Chemistry and Biochemistry.

Dr. DuBois research is focused on understanding the molecular and genetic basis for colorectal cancer. My laboratory has several projects underway to understand the molecular mechanisms by which prostaglandins and other inflammatory mediators affect epithelial biology, the tumor microenvironment, carcinogenesis and development.

1. Xia D., Wang D., Kim S.H., Katoh H., DuBois R.N., (2012) “Prostaglandin E2 promotes intestinal tumor growth via DNA methylation,” Nature Medicine, 18, 224-226.

2. Ding Q., Chang C.J., Xie X., Xia W., Yang J.Y., Wang S.C., Wang Y., Xia J., Chen L., Cai C., Li H., Yen C.J., Kuo H.P., Lee D.F., Lang J., Huo L., Cheng X., Chen Y.J., Li C.W., Jeng L.B., Hsu J.L., Li L.Y., Tan A., Curley S.A., Ellis L.M., DuBois R.N., Hung M.C. (2011) “APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis,” J. Clin Invest. 121, 4526-4536.

3. Kim S.H., Park Y.H, Kim S.W., Lee J.S., Wang D. and DuBois R.N. (2011) “ANGPTL4 induction by Prostaglandin E2 under hypoxic conditions promotes colorectal carcinogenesis,” Cancer Res. 71, 7010-7020.

4. Wang D., Ning W., Xie D., Guo L. and DuBois R.N. (2012) “Peroxisome Activated Receptor delta confers resistance to PPAR gamma-induced apoptosis in colorectal cancer cells,” Oncogene 31, 1013-1023.

5. Holla V.R., Wu H., Shi Q., Menter D.G. and DuBois R.N. (2011) “Nuclear Orphan Receptor NR4A2 modulates fatty acid oxidation pathways in colorectal cancer,” J. Biol.Chem. 286, 30003- 30009. [Epub 2011 Jul 10]

6. Kim S.H., Xia D., Kim S.W., Holla V., Menter D.G .and DuBois R.N. (2010) “Human enhancer of filamentation-1 is a mediator of hypoxia-inducible factor-1 alpha- mediated migration in colorectal carcinoma cells,” Cancer Res. 70, 4054-4063.

7. Speirs C., Jernigan K.K., Kim S.H., Cha Y.I., Lin F., Sepich D.S., DuBois R.N., Lee E. and Solnica-Krezel L. (2010) “Prostaglandin signaling stimulates gastrulation movements by limiting cell adhesion through Snail stabilization,” Development, 137, 1327-1337.

8. Xia D., Holla V.R,. Wang D., Menter D.G. and DuBois R.N. (2010) “HEF1 is a crucial mediator of the proliferative effects of prostaglandin E2 on colon cancer cells,” Cancer Res. 70, 824-831.