The Puerto Rico Cancer Control Community Outreach Project (PRCCCOP) began as a two-year pilot project in 2006, with a goal of engaging community, government, and non-governmental organizations in coordinating tobacco control efforts in Puerto Rico. This pilot exceeded its expectations over its two years existence and was transitioned to a full program that continued efforts in tobacco control, but also expanded our focus to include efforts to increase breast and cervical cancer (B&C) screening and Human Papilloma Virus (HPV) vaccination uptake. Over the last five years, the PRCCCOP has worked with community partners and U54 trainees in identifying areas of cancer control need and building capacity for both community-based participatory research and program implementation.